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In addition, NRF2 also regulates the expression of ferritin subunits to promote free Fe 2+ sequestration, which can inhibit Fe 2+ -dependent free radical generation, and thus reducing the Fe 2+ -mediated toxicity [36]
Over time, oxidative stress can lead to cellular damage, which is strongly linked to cognitive decline, mild cognitive impairment, Alzheimers disease, and other neurological disorders
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